Antibodies, also known as immunoglobulins, are Y-shaped proteins that are produced by the immune system to recognize and neutralize foreign substances, such as viruses, bacteria, and toxins. They are an important part of the body's defense mechanism against infections and diseases.
Antibodies are made up of two heavy chains and two light chains that are linked by disulfide bonds. The tips of the Y-shaped structure are called the antigen-binding sites, which are responsible for recognizing and binding to specific antigens on the surface of foreign substances. The rest of the antibody, known as the constant region, interacts with other immune cells to trigger the elimination of the foreign substance.
Antibodies are generated by B cells, which are a type of white blood cell. B cells produce a diverse repertoire of antibodies through a process called somatic recombination, where segments of antibody genes are shuffled and combined to create unique antibody sequences. This allows the immune system to recognize a wide range of foreign substances.
At Biointron, we specialize in antibody discovery and development. Our high-throughput single B cell screening platform can screen millions of plasma B cells from immunized animals to identify rare, antigen-specific antibodies. We also offer a rapid and reliable recombinant antibody production service, which can provide you with a purified, guaranteed amount of recombinant antibody in just two weeks.
If you're interested in learning more about our antibody discovery and development services, please don’t hesitate to contact us.
Antibody specificity refers to an antibody's ability to selectively bind to a unique epitope on a target antigen while avoiding interactions with unrelated antigens. This property arises from the highly specialized antigen-binding site located in the variable region of the antibody, which determines its unique binding characteristics.
Antibody affinity refers to the strength of the binding interaction between a single antigen epitope and the paratope (binding site) of an antibody. This interaction is a fundamental measure of how well an antibody recognizes its specific antigen target.
Recombinant antibodies are produced using genetic engineering techniques, unlike traditional antibody production, where the immune system generates antibodies without direct control over their sequence. By introducing genes encoding antibody fragments into host cells, such as bacteria or mammalian cells, recombinant antibodies can be expressed, purified, and deployed for applications including research, diagnostics, and therapeutics.
Recombinant antibody expression is a biotechnological process that involves engineering and producing antibodies outside their natural context using recombinant DNA technology.
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