Together with the Chinese Antibody Society, Biointron's latest webinar features Shun Zhou, Ph.D, the R&D Director at Cyagen:
“Accelerating Antibody Discovery with Fully Human Antibody Mouse HUGO-Ab™ and Single B Cell Screening Technology AbDrop™”
This topic explores the revolutionary potential of the genome-edited mouse HUGO-Ab, where endogenous VH and VL genes are replaced by fully human VH and VL genes in situ, enabling the generation of fully human antibody molecules. When combined with microfluidic technology-enhanced single B cell screening, this approach allows for the high-throughput and efficient discovery of antibody drug molecules.
About the Speaker:
Shun Zhou has a Ph.D. in Molecular Biology and Genetics from the Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, and is a Postdoctoral Fellow in the Department of Biomedical Engineering at Tufts University, USA. With over 10 years of research and development experience in molecular biology, cell biology, and genetics, his work has been published in more than 10 articles in journals such as PNAS and Acta Biomaterialia. Currently serving as the R&D Director at Cyagen Bioscience, he has extensive project research experience in gene editing technologies, Gene and Cell therapy drug research technologies, and antibody discovery technologies, participating in several preclinical projects for antibody drugs and gene and cell therapy drugs.
Antibody specificity refers to an antibody's ability to selectively bind to a unique epitope on a target antigen while avoiding interactions with unrelated antigens. This property arises from the highly specialized antigen-binding site located in the variable region of the antibody, which determines its unique binding characteristics.
Antibody affinity refers to the strength of the binding interaction between a single antigen epitope and the paratope (binding site) of an antibody. This interaction is a fundamental measure of how well an antibody recognizes its specific antigen target.
Recombinant antibodies are produced using genetic engineering techniques, unlike traditional antibody production, where the immune system generates antibodies without direct control over their sequence. By introducing genes encoding antibody fragments into host cells, such as bacteria or mammalian cells, recombinant antibodies can be expressed, purified, and deployed for applications including research, diagnostics, and therapeutics.
Recombinant antibody expression is a biotechnological process that involves engineering and producing antibodies outside their natural context using recombinant DNA technology.
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